Altered phagocyte function precedes death in polymicrobial sepsis
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چکیده
..................................................................................................................... vii TABLE OF CONTENTS ................................................................................................... ix LIST OF TABLES ............................................................................................................. xi LIST OF FIGURES .......................................................................................................... xii LIST OF ABBREVIATIONS .......................................................................................... xiv 1 CHAPTER ONE: GENERAL INTRODUCTION .....................................................
منابع مشابه
Zinc Dyshomeostasis during Polymicrobial Sepsis in Mice Involves Zinc 1 Transporter Zip14 and Can Be Overcome by Zinc Supplementation 2 3 Corresponding Author
36 Integrity of the immune system is particularly dependent on the availability of zinc. 37 Recent data suggest that zinc is involved in the development of sepsis, a life 38 threatening systemic inflammation with high death rates, but with limited therapeutic 39 options. Altered cell zinc transport mechanisms could contribute to the inflammatory 40 effects of sepsis. In this regard, Zip14, a zi...
متن کاملZinc dyshomeostasis during polymicrobial sepsis in mice involves zinc transporter Zip14 and can be overcome by zinc supplementation.
Integrity of the immune system is particularly dependent on the availability of zinc. Recent data suggest that zinc is involved in the development of sepsis, a life-threatening systemic inflammation with high death rates, but with limited therapeutic options. Altered cell zinc transport mechanisms could contribute to the inflammatory effects of sepsis. Zip14, a zinc importer induced by proinfla...
متن کاملIL-17 receptor signaling is required to control polymicrobial sepsis
Sepsis is a systemic inflammatory response resulting from the inability of the host to contain the infection locally. Previously, we demonstrated that during severe sepsis there is a marked failure of neutrophil migration to the infection site, which contributes to dissemination of infection, resulting in high mortality. IL-17 plays an important role in neutrophil recruitment. Herein, we invest...
متن کاملIncreased resistance against acute polymicrobial sepsis in mice challenged with immunostimulatory CpG oligodeoxynucleotides is related to an enhanced innate effector cell response.
Recent reports support the concept that the major defect in polymicrobial sepsis is an impaired immunologic response to infection. Oligodeoxynucleotides containing CpG sequence motifs (CpG-ODN) were previously shown to induce immune protection in models of chronic infection with intracellular bacteria, parasites, and viruses due to their ability to augment IFN-gamma-dependent Th1 responses. Her...
متن کاملCXCL1 contributes to host defense in polymicrobial sepsis via modulating T cell and neutrophil functions.
Severe bacterial sepsis leads to a proinflammatory condition that can manifest as septic shock, multiple organ failure, and death. Neutrophils are critical for the rapid elimination of bacteria; however, the role of neutrophil chemoattractant CXCL1 in bacterial clearance during sepsis remains elusive. To test the hypothesis that CXCL1 is critical to host defense during sepsis, we used CXCL1-def...
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تاریخ انتشار 2014